Custodiol® HTK-Solution


The solution is left in the organ vasculature during hypothermic storage and transportation (not for continuous perfusion) to the recipient.

Due to high systemic tolerance, all kinds of operation procedures in ischemic organs are possible; e.g. heart surgery, kidney tumor-resection and split-liver-donation.

Custodiol® HTK (Histidine-Tryptophan-Ketoglutarate) is a clinically proven flush and preservation solution used for multi-organ protection (heart, liver, kidney, pancreas and lungs).

Custodiol® HTK solution is a ready to use high flow, low potassium solution designed to remain in the organ vasculature during hypothermic storage and transportation to the recipient surgery. At just 10 mmol/L, the low potassium content of Custodiol HTK makes preflushing the solution from the organ unnecessary prior to implantation.

Custodiol® has been used in almost 2 million cardiac procedures in Europe

NOTE: Custodiol® has not yet been submitted for regulatory approval in the Nordic countries. Individual permits from local health authorities must be obtained prior to use.

Bags containing 1 or 2 liter Custodiol®

The Custodiol® bag, Cryovac M312, is made of a new generation of advanced films for medical solutions. The material is based on exclusive multilayer technology resulting in a film that is exceptionally clear, extremely durable with a wide range of superior physical properties.

Pack size

6 x 1 liter and 4 x 2 liter

More Information

Healthcare Professional Information-Summary of the products Characteristics(SmPC)

Please note

Whilst the Patient Information Leaflets (PIL) and Summary of Product Characteristics (SmPC) product information is intended to be helpful, we stress that this is not intended to, and should not, replace the advice of a qualified medical professional.

If you experience any side effects that cause you concern as a result of the use of any of our products and wish to notify us directly please get in touch via our contact page.


Please note that the above links are relevant to the local marketing authorisation requirements only. Patients and carers in Denmark can find similar information at however, if you are from outside Denmark, your local country requirements may differ. Please refer to your local country patient information leaflet(PIL) or summary product characteristic (SPC), if you are a patient or health care professional (HCP) respectively, for further guidance.

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