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In 2017, ATNAHS added Kytril (granisetron) to their portfolio of heritage brands

In 2017, ATNAHS were proud to have acquired the marketing and distribution rights to Kytril (granisetron) from Roche.

Kytril is indicated for the prevention and treatment of emesis, specifically Chemotherapy-Induced Nausea and Vomiting (CINV), Radiotherapy-Induced Nausea and Vomiting (RINV) and Post-Operative Nausea and Vomiting (PONV).1

History and development of Kytril (granisetron)

Scientist working in a lab

The Kytril molecule granisetron was developed by chemists working at the British company Beecham around 1988.2

Kytril (granisetron) was licensed in the UK in 1991 by SmithKline Beecham with the commercial rights subsequently transferred to Roche Products.3

Image of Wesley Miner and Gareth Sanger

Whilst working at Beecham, Wesley Miner and Gareth Sanger discovered that 5-HT3 serotonin receptor antagonists were extremely efficacious pharmacological agents for preventing and treating anti-cancer therapy-induced nausea and vomiting.

Their seminal experimental work translated extremely well to the clinic where Kytril (granisetron) was shown to be highly efficacious in patients.4

Woman wearing glasses

Kytril (granisetron) is recommended by the National Comprehensive Cancer Network 2020 (NCCN)5

Today Kytril (granisetron) continues to be recommended for nausea and vomiting associated with cancer chemotherapy.5

CINV market expected to reach nearly $1.9 billion by the end of 20266

Disclaimer

All of the information presented above is factual historical information that is available in the public domain and is included in good faith. It is not the intention to make any new or fresh claims nor to be promotional for the product in question.

References

  1. Granisetron 1mg film coated tablets, Summary of Product Characteristics.
  2. New Drug Approvals. Available from https://newdrugapprovals.org/2013/12/31/granisetron/ [Last accessed January 2021].
  3. MHRA Public Assessment Report UK/H/1929/001/DC. Available from https://mhraproducts4853.blob.core.windows.net/docs/c49ecf72357407ee7758dfa917b6f46ea1521709. (Last accessed January 2021).
  4. The History of Modern Biomedicine. Wes Miner. Available from http://www.histmodbiomed.org/article/miner-wes.html [Last accessed January 2021].
  5. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Oncology: Antiemesis. v2.2020. Available from https://www.nccn.org/professionals/physician_gls/pdf/antiemesis.pdf [Last accessed January 2021].
  6. CINV Existing and Pipeline Drugs Market Size By Product Types, BMRC 2928, Sep 2020. Available from https://industrystatsreport.com/Lifesciences-and-Healthcare/CINV-Existing-and-Pipeline-Drugs-Market-Industry-Report/Summary [Last accessed February 2021].

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